SOT antisense therapy
What is SOT antisense therapy?
SOT (Supportive Oligonucleotide Therapy) antisense therapy is a treatment in which an antisense that is thought to be effective in suppressing cancer stem cells is created based on the results of gene expression analysis of CTCs obtained from cancer stem cell testing , and is injected once or twice.The antisense works by inhibiting the synthesis of proteins required by cancer cells to suppress the proliferation of cancer cells or by inducing apoptosis in cancer cells, which is expected to have an antitumor effect.
Mechanism of action of SOT antisense therapy
Cells contain genes (DNA), and proteins are synthesized from DNA as needed. DNA is made up of two strands, the strand that carries genetic information is called the sense strand, and the other strand that does not carry genetic information is called the antisense strand. Protein synthesis involves copying the information on the sense strand of DNA into RNA, which is then stripped of unnecessary parts to create mRNA, which is then delivered to the ribosome for synthesis.
On the other hand, unlike viruses and other microorganisms, human cells have RNA that is made up of a single strand. Since double-stranded RNA does not exist, if double-stranded RNA is present, it will be quickly degraded by enzymes. SOT antisense therapy makes use of this mechanism. Specifically, by administering RNA (antisense) that can bind to the abnormal mRNA produced by cancer cells, double-stranded RNA is produced, which is then degraded by enzymes to inhibit the synthesis of necessary proteins.
Treatment Overview
This treatment is an elective medical treatment.
Flow of SOT antisense therapy
Step 1: Interview and examination
Step 2: Cancer stem cell test (Oncotrace RGCC + Onconomics Plus)
Step 3: Antisense drug production is outsourced (approximately 4 to 6 weeks)
Step 4: Administration (approximately 1 hour)
Treatment period and frequency
The treatment plan will vary depending on the patient's condition and symptoms, so we will decide after you have undergone an examination and tests.
Cost (private medical treatment)
Please note that treatment will vary depending on the patient's condition and symptoms, so we will inform you of the treatment plan after it has been decided.
Risks and Side Effects
To date, no serious side effects have been reported with this treatment.
Rarely, mild side effects such as headache or rash may occur.
未承認医薬品等を用いた自由診療について
Unapproved drugs, etc.
The unapproved drugs used in this treatment have not yet been approved under the Pharmaceuticals and Medical Devices Act. In Japan, unapproved drugs and medical devices can be used at the doctor's own risk.
Acquisition route etc.
Available through a domestic distributor.
Availability of domestically approved drugs, etc.
There are no other drugs approved in Japan that have the same properties as the one used in this treatment.
Information on safety in foreign countries
Currently, there is no information regarding safety in other countries.